Study record

Mitochondria-Endoplasmic Reticulum Crosstalk in Pancreatic β-Cell Stress: A Driver of Diabetes

Niinuma SA, Takemoto AS, Khalil WJ et al. · Cells · 2026

ReviewMOTS-c administeredEvidence tier R
PubMed 42882431doi:10.3390/cells15191733Full text (PMC)Compare with another study

What this study reported

Reviewed endoplasmic reticulum-mitochondria crosstalk in pancreatic beta-cell failure in type 2 diabetes and listed MOTS-c among strategies discussed as targeting this interface, contrasting rodent and human data.

Limitations

Narrative review without systematic search; MOTS-c is mentioned only in passing as a candidate, with no appraisal of the supporting studies.

Study record

Annotated fields for this study
Study modelReview
Substance studiedMOTS-c administeredSynthetic MOTS-c was given to cells, animals or people.
SpeciesNot reported
System studiedNarrative review of mitochondria-endoplasmic reticulum crosstalk in pancreatic beta-cell stress
PopulationNot reported
DesignNarrative review
Sample size as reportedNot reported
Control groupNot reported
Route (data field only)Not reported
Endpoints measuredbeta-cell stress pathways; mitochondria-associated membrane integrity; candidate therapeutic strategies
Pathways measuredOxidative stress · Autophagy / mitophagy · Apoptosis
Research areasMetabolic · Mitochondrial biology
Evidence tierR — Review (context, not evidence)
Publication typesJournal Article, Review

Appraisal

Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.

Relevance to MOTS-c
Peripheral
Model applicability
n/a
Sample size
n/a
Controls
n/a
Outcome validity
n/a
Support for its own conclusion
n/a

Provenance

  • Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
  • Annotated from the published abstract.
  • Editorial review: approved (2026-11-11).
  • Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.