Study record
Mitochondrial-derived peptides in female reproduction: Emerging regulators of oocyte competence and novel therapeutic opportunities for infertility
Rostami Z, Galeshi M, Mosapour A · Tissue Cell · 2026
ReviewRelated mitochondrial peptideEvidence tier R
What this study reported
Reviewed evidence that MOTS-c, humanin and SHLP2 decline with age in humans alongside declining oocyte quality, and cited a reported reduction in serum MOTS-c in polycystic ovary syndrome as preliminary and unreplicated. Proposed that MDP levels in follicular fluid and granulosa cells be measured directly to test biomarker potential in assisted reproduction.
Limitations
Hypothesis-driven review rather than primary data; the authors note that the key MOTS-c clinical link is unreplicated and lacks ovarian sampling.
Study record
| Study model | Review |
|---|---|
| Substance studied | Related mitochondrial peptideThe paper is mainly about another mitochondrial-derived peptide, such as humanin. |
| Species | Not reported |
| System studied | Hypothesis-driven review of mitochondrial-derived peptides in female reproduction, covering MOTS-c, humanin and SHLP2 |
| Population | Not reported |
| Design | Narrative review with structured literature search |
| Sample size as reported | 87 records retained from 312 identified |
| Control group | Not reported |
| Route (data field only) | Not reported |
| Endpoints measured | age-related changes in MDP levels; proposed mechanisms in oocyte competence; candidate biomarker applications in assisted reproduction |
| Pathways measured | AMPK signalling · Oxidative stress · Apoptosis |
| Research areas | Reproductive · Aging · Mitochondrial biology |
| Evidence tier | R — Review (context, not evidence) |
| Publication types | Journal Article, Review |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Indirect
- Model applicability
- n/a
- Sample size
- n/a
- Controls
- n/a
- Outcome validity
- n/a
- Support for its own conclusion
- n/a
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.