Study record
AGEs-RAGE Axis and Mitochondrial-Derived Peptides in Advanced Chronic Kidney Disease: Interconnected Pathways Beyond Inflammation and Nutrition
Suliman ME, Rahman A, Qureshi AR et al. · Antioxidants (Basel) · 2026
What this study reported
Measured higher advanced glycation end-products and lower mitochondrial-derived peptides, including MOTS-c, in adults with chronic kidney disease compared with controls. Reported that MOTS-c was inversely associated with advanced glycation end-products and with the AGEs/sRAGE ratio, while humanin was independently associated with AGEs and sRAGE measures.
Limitations
Cross-sectional design with MOTS-c one of several peptides measured; single-centre transplantation cohort; ELISA-based peptide quantification without orthogonal confirmation.
Study record
| Study model | Human observational |
|---|---|
| Substance studied | Related mitochondrial peptideThe paper is mainly about another mitochondrial-derived peptide, such as humanin. |
| Species | human |
| System studied | Adults with kidney failure undergoing living-donor kidney transplantation and controls; serum AGEs, RAGE isoforms and MDPs by ELISA |
| Population | adults with kidney failure awaiting living-donor kidney transplantation and controls |
| Design | Cross-sectional cohort |
| Sample size as reported | 240 participants (160 with kidney failure, 80 controls) |
| Control group | controls without chronic kidney disease |
| Route (data field only) | Not reported |
| Endpoints measured | serum MOTS-c; humanin and humanin-like 1; advanced glycation end-products and sRAGE isoforms; C-reactive protein; protein-energy wasting measures |
| Pathways measured | Oxidative stress · Inflammation |
| Research areas | Kidney · Mitochondrial biology · Inflammation & immunity |
| Evidence tier | B — Other human study |
| Publication types | Journal Article |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Indirect
- Model applicability
- Human
- Sample size
- Adequate
- Controls
- Appropriate
- Outcome validity
- Validated biomarker
- Support for its own conclusion
- Moderate
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.