Study record
Mitochondrial-derived peptides (MDPs) activated by physical exercise as therapeutic targets for metabolic disorders: A systematic review
Ayubi N, Wibawa JC, Kurnaz M et al. · Physiol Int · 2026
ReviewEndogenous MOTS-c measuredEvidence tier R
What this study reported
Systematically reviewed nine studies of exercise and mitochondrial-derived peptides including MOTS-c, and reported that most described a trend toward higher MDP levels after exercise. The authors noted that the small number of studies and variation in design, participants and exercise protocols limit interpretation.
Limitations
Only nine heterogeneous studies were included, with no meta-analysis or formal risk-of-bias grading reported in the abstract; human data were described as particularly limited.
Study record
| Study model | Review |
|---|---|
| Substance studied | Endogenous MOTS-c measuredNaturally occurring MOTS-c was measured; nothing was given. |
| Species | Not reported |
| System studied | Systematic review of nine studies on exercise and mitochondrial-derived peptide levels, including MOTS-c |
| Population | Not reported |
| Design | Systematic review (PRISMA) |
| Sample size as reported | 9 included studies from 435 identified records |
| Control group | Not reported |
| Route (data field only) | Not reported |
| Endpoints measured | circulating mitochondrial-derived peptide levels after exercise; humanin and MOTS-c responses |
| Pathways measured | Not reported |
| Research areas | Exercise · Metabolic · Mitochondrial biology |
| Evidence tier | R — Review (context, not evidence) |
| Publication types | Journal Article, Systematic Review, Review |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Direct
- Model applicability
- n/a
- Sample size
- n/a
- Controls
- n/a
- Outcome validity
- n/a
- Support for its own conclusion
- n/a
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.