Study record
Mitochondria-derived peptide hydrogel augments mitochondrial transplantation for promoting cardiac repair via macrophage metabolic reprogramming
Li H, Zhang Y, Jian Y et al. · Bioact Mater · 2027
What this study reported
Reported that a MOTS-c-Q11 peptide hydrogel extended the survival and enzyme activity of isolated mitochondria and increased their internalisation by macrophages through an AMPK-dependent mechanism. Reported that in a rat myocardial infarction model the combined system was associated with less M1 macrophage infiltration, less cardiomyocyte damage and improved cardiac function and remodelling.
Limitations
MOTS-c is used as part of a conjugated biomaterial rather than as the free peptide, so its independent contribution is hard to isolate; group sizes not reported in the abstract; a single rat infarction model with short follow-up.
Study record
| Study model | Animal study (in vivo) |
|---|---|
| Substance studied | MOTS-c analogue or derivativeA modified peptide or drug derived from MOTS-c, which is not the same molecule. |
| Species | rat |
| System studied | MOTS-c conjugated to a self-assembling Q11 peptide as a hydrogel carrier for isolated mitochondria; rat myocardial infarction model and macrophages |
| Population | Not reported |
| Design | Biomaterial development with cell culture and controlled animal experiments |
| Sample size as reported | not reported |
| Control group | untreated infarcted animals and mitochondria without the peptide hydrogel |
| Route (data field only) | other |
| Endpoints measured | survival of isolated mitochondria; mitochondrial internalisation by macrophages; macrophage glycolysis and oxidative phosphorylation; M1 polarisation and reactive oxygen species; cardiac function and remodelling |
| Pathways measured | AMPK signalling · Inflammation · Oxidative stress |
| Research areas | Cardiovascular · Inflammation & immunity · Mitochondrial biology |
| Evidence tier | C — Animal in vivo |
| Publication types | Journal Article |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Indirect
- Model applicability
- Mammalian
- Sample size
- Not reported
- Controls
- Appropriate
- Outcome validity
- Surrogate
- Support for its own conclusion
- Moderate
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.