Study record
Mitochondrial dysfunction in ARDS: unraveling the regulatory networks and therapeutic opportunities
Li YH, Wang M, Wan K et al. · Front Immunol · 2026
ReviewMOTS-c administeredEvidence tier R
What this study reported
Reviewed mitochondrial dysfunction and glycolytic reprogramming in acute respiratory distress syndrome and listed MOTS-c among mitochondria-targeted agents reported to show promise in preclinical models.
Limitations
Narrative review without systematic search; MOTS-c is mentioned only as one candidate agent among many, with no appraisal of the underlying studies.
Study record
| Study model | Review |
|---|---|
| Substance studied | MOTS-c administeredSynthetic MOTS-c was given to cells, animals or people. |
| Species | Not reported |
| System studied | Narrative review of mitochondrial dysfunction in acute respiratory distress syndrome |
| Population | Not reported |
| Design | Narrative review |
| Sample size as reported | Not reported |
| Control group | Not reported |
| Route (data field only) | Not reported |
| Endpoints measured | mitochondrial dysfunction mechanisms in ARDS; metabolic reprogramming; candidate mitochondria-targeted agents |
| Pathways measured | Inflammation · Oxidative stress · Autophagy / mitophagy |
| Research areas | Lung · Mitochondrial biology · Inflammation & immunity |
| Evidence tier | R — Review (context, not evidence) |
| Publication types | Journal Article, Review |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Peripheral
- Model applicability
- n/a
- Sample size
- n/a
- Controls
- n/a
- Outcome validity
- n/a
- Support for its own conclusion
- n/a
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.