Study record
Emerging regulators of human physiology and disease; sORF-encoded microproteins
Mustafa AM, Ali RM, Omar SS et al. · Epigenomics · 2026
ReviewRelated mitochondrial peptideEvidence tier R
What this study reported
Reviewed the classification, discovery and regulation of short open reading frame-encoded microproteins and cited MOTS-c alongside humanin, myoregulin and others as examples of microproteins implicated in cardiometabolic disease, neurodegeneration and cancer.
Limitations
Narrative review with no systematic search; MOTS-c appears as one illustrative example rather than a focus, so no appraisal of the MOTS-c evidence base is given.
Study record
| Study model | Review |
|---|---|
| Substance studied | Related mitochondrial peptideThe paper is mainly about another mitochondrial-derived peptide, such as humanin. |
| Species | Not reported |
| System studied | Narrative review of short open reading frame-encoded microproteins, MOTS-c among the examples |
| Population | Not reported |
| Design | Narrative review |
| Sample size as reported | Not reported |
| Control group | Not reported |
| Route (data field only) | Not reported |
| Endpoints measured | classification and discovery of microproteins; epigenetic and epitranscriptomic regulation; disease roles of selected microproteins |
| Pathways measured | Other |
| Research areas | Mitochondrial biology · Metabolic |
| Evidence tier | R — Review (context, not evidence) |
| Publication types | Journal Article, Review |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Peripheral
- Model applicability
- n/a
- Sample size
- n/a
- Controls
- n/a
- Outcome validity
- n/a
- Support for its own conclusion
- n/a
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.