Study record
Circulating mitochondrial-derived microproteins at rest and in response to an acute bout of endurance exercise in individuals with cerebral palsy
Horwath O, Corell L, Wan J et al. · Exp Physiol · 2026
Human obs.Endogenous MOTS-c measuredEvidence tier B
What this study reported
Measured plasma MOTS-c, humanin and SHMOOSE in adults with cerebral palsy and typically developing participants and found comparable basal levels despite lower muscle mass and peak oxygen uptake in the cerebral palsy group. Reported no or only modest changes in circulating MDPs after an acute endurance exercise bout, with no differences between groups.
Limitations
Small group sizes not reported in the abstract; single post-exercise sampling point; in-house ELISA without external validation and heterogeneous exercise modes between groups.
Study record
| Study model | Human observational |
|---|---|
| Substance studied | Endogenous MOTS-c measuredNaturally occurring MOTS-c was measured; nothing was given. |
| Species | human |
| System studied | Adults with cerebral palsy using running frames and typically developing adults and adolescents; plasma MDPs before and after endurance exercise |
| Population | adults with cerebral palsy (GMFCS II-IV) and typically developing adults and adolescents |
| Design | Cross-sectional comparison with an acute exercise bout; MOTS-c measured |
| Sample size as reported | not reported |
| Control group | typically developing adults and adolescents |
| Route (data field only) | Not reported |
| Endpoints measured | plasma MOTS-c; plasma humanin and SHMOOSE; peak oxygen uptake; muscle thickness; habitual physical activity |
| Pathways measured | Not reported |
| Research areas | Exercise · Nervous system · Mitochondrial biology · Skeletal muscle |
| Evidence tier | B — Other human study |
| Publication types | Journal Article |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Direct
- Model applicability
- Human
- Sample size
- Small
- Controls
- Appropriate
- Outcome validity
- Exploratory
- Support for its own conclusion
- Moderate
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.