Study record
Mitochondrial peptide MOTS-c suppresses systemic and cardiac inflammasome activation in a diabetic rat model
Mills AR, de Souza A, Pham T et al. · Exp Physiol · 2026
AnimalMOTS-c administeredEvidence tier C
What this study reported
Reported that administered MOTS-c was associated with lower fasting blood glucose and circulating C-reactive protein and with selective changes in plasma IL-10 and IL-1beta in diabetic rats. Reported lower NLRP3, ASC and cleaved caspase-1 staining in left ventricular tissue after MOTS-c administration.
Limitations
Male rats only in a single chemically induced diabetes model, with group sizes not reported in the abstract; immunohistochemistry is semi-quantitative and no cardiac functional endpoints were reported.
Study record
| Study model | Animal study (in vivo) |
|---|---|
| Substance studied | MOTS-c administeredSynthetic MOTS-c was given to cells, animals or people. |
| Species | rat |
| System studied | Male Sprague-Dawley rats with high-fat diet and streptozotocin-induced type 2 diabetes |
| Population | Not reported |
| Design | Controlled animal experiment |
| Sample size as reported | not reported |
| Control group | untreated diabetic rats |
| Route (data field only) | Not reported |
| Endpoints measured | fasting blood glucose; C-reactive protein; plasma IL-10 and IL-1beta; left ventricular NLRP3, ASC and cleaved caspase-1; lipid and uric acid measures |
| Pathways measured | Inflammation · Insulin & glucose handling |
| Research areas | Cardiovascular · Metabolic · Inflammation & immunity |
| Evidence tier | C — Animal in vivo |
| Publication types | Journal Article |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Direct
- Model applicability
- Mammalian
- Sample size
- Not reported
- Controls
- Appropriate
- Outcome validity
- Surrogate
- Support for its own conclusion
- Moderate
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.