Study record
Reduced Circulating MOTS-c Levels in Hashimoto's Thyroiditis Reflect Integrated Autoimmune and Metabolic Dysregulation: A Cross-Sectional Study
Sonay HO, Duran EN, Algemi M et al. · J Clin Med · 2026
What this study reported
Measured lower circulating MOTS-c in patients with Hashimoto's thyroiditis than in matched controls, with inverse correlations with body mass index, fasting glucose, HbA1c, HOMA-IR, thyroid-stimulating hormone, C-reactive protein and thyroid autoantibodies. Reported that Hashimoto's thyroiditis and HOMA-IR were independent determinants of lower MOTS-c in regression analysis.
Limitations
Cross-sectional design cannot establish direction; single-centre sample measured by ELISA at one time point; medication and iodine status largely unaccounted for beyond levothyroxine use.
Study record
| Study model | Human observational |
|---|---|
| Substance studied | Endogenous MOTS-c measuredNaturally occurring MOTS-c was measured; nothing was given. |
| Species | human |
| System studied | Patients with Hashimoto's thyroiditis and age- and sex-matched healthy controls; circulating MOTS-c |
| Population | adults with Hashimoto's thyroiditis and age- and sex-matched healthy controls |
| Design | Cross-sectional case-control study |
| Sample size as reported | 180 participants (90 with Hashimoto's thyroiditis, 90 controls) |
| Control group | age- and sex-matched healthy controls |
| Route (data field only) | Not reported |
| Endpoints measured | circulating MOTS-c; HOMA-IR and fasting glucose; HbA1c and body mass index; thyroid-stimulating hormone and thyroid autoantibodies; C-reactive protein |
| Pathways measured | Insulin & glucose handling · Inflammation |
| Research areas | Metabolic · Inflammation & immunity · Mitochondrial biology |
| Evidence tier | B — Other human study |
| Publication types | Journal Article |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Direct
- Model applicability
- Human
- Sample size
- Adequate
- Controls
- Appropriate
- Outcome validity
- Validated biomarker
- Support for its own conclusion
- Moderate
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.