Study record
Elevated Serum Nardilysin Is Inversely Associated with Cardiovascular Disease in Kidney Transplant Recipients
Sączek A, Batko K, Banaszkiewicz M et al. · Kidney Blood Press Res · 2026
What this study reported
Measured higher serum nardilysin and MOTS-c in kidney transplant recipients than in age-matched controls over a median follow-up of about 29 months. Reported no significant associations between MOTS-c and cardiometabolic features, and a non-significant trend toward lower allograft loss risk with higher MOTS-c, while nardilysin was inversely associated with prevalent cardiovascular disease.
Limitations
MOTS-c was a secondary marker alongside nardilysin; single-centre observational design with a small control group and few outcome events; residual confounding likely.
Study record
| Study model | Human observational |
|---|---|
| Substance studied | Endogenous MOTS-c measuredNaturally occurring MOTS-c was measured; nothing was given. |
| Species | human |
| System studied | Kidney transplant recipients and age-matched controls; serum nardilysin and MOTS-c by ELISA |
| Population | kidney transplant recipients and age-matched control patients |
| Design | Observational cohort with follow-up |
| Sample size as reported | 150 patients (118 kidney transplant recipients, 32 controls) |
| Control group | age-matched non-transplant patients |
| Route (data field only) | Not reported |
| Endpoints measured | serum MOTS-c; serum nardilysin; prevalent cardiovascular disease; renal allograft loss; all-cause mortality and eGFR decline |
| Pathways measured | Other |
| Research areas | Kidney · Cardiovascular · Metabolic |
| Evidence tier | B — Other human study |
| Publication types | Journal Article |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Indirect
- Model applicability
- Human
- Sample size
- Adequate
- Controls
- Limited
- Outcome validity
- Clinical outcome
- Support for its own conclusion
- Moderate
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.