Study record
MOTS-c attenuates hyperoxia-induced neonatal cardiac injury by inhibiting oxeiptosis via maintaining the KEAP1-PGAM5 interaction
Li SH, Chen SQ, Lu T et al. · Life Sci · 2026
AnimalSeveralEvidence tier CAlso: Cell study (in vitro)
What this study reported
Measured lower serum MOTS-c in neonatal mice exposed to hyperoxia, which showed cardiac hypertrophy, fibrosis and dysfunction, and reported that administered MOTS-c was associated with attenuation of these changes. Reported that hyperoxia activated a KEAP1-PGAM5-AIFM1 oxeiptosis axis and that MOTS-c interacted with KEAP1, with KEAP1 overexpression abolishing the effect in cardiomyocytes.
Limitations
Male neonatal mice with group sizes not reported in the abstract; one immortalised rat cardiomyocyte line in vitro; only short-term outcomes assessed.
Study record
| Study model | Animal study (in vivo) |
|---|---|
| Substance studied | SeveralMore than one of these is central to the paper (common for reviews). |
| Species | mouse, rat |
| System studied | Hyperoxia-exposed neonatal C57BL/6 mice and hyperoxia-exposed H9C2 rat cardiomyocytes |
| Population | Not reported |
| Design | Controlled animal experiment with cell culture experiments |
| Sample size as reported | not reported |
| Control group | normoxia-exposed and vehicle-treated hyperoxia-exposed animals and cells |
| Route (data field only) | Not reported |
| Endpoints measured | serum MOTS-c content; cardiac hypertrophy and fibrosis; cardiac function; oxeiptosis and oxidative stress markers; KEAP1-PGAM5-AIFM1 axis |
| Pathways measured | Oxidative stress · NRF2 / antioxidant response · Apoptosis |
| Research areas | Cardiovascular · Mitochondrial biology |
| Evidence tier | C — Animal in vivo |
| Publication types | Journal Article |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Direct
- Model applicability
- Mammalian
- Sample size
- Not reported
- Controls
- Appropriate
- Outcome validity
- Surrogate
- Support for its own conclusion
- Moderate
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.