Study record
MOTS-c is associated with oxidative stress and arterial stiffness in peritoneal dialysis patients: a pilot study
Musolino M, Roumeliotis A, Roumeliotis S et al. · Int Urol Nephrol · 2026
What this study reported
Measured MOTS-c in serum, urine and dialysate of peritoneal dialysis patients and reported that higher urinary MOTS-c was associated with lower advanced oxidation protein products and with higher pulse wave velocity and left ventricular systolic function. Reported that higher dialysate MOTS-c was associated with lower pulse wave velocity and lower blood pressure.
Limitations
Small single-centre pilot with no control group and cross-sectional correlations only; multiple comparisons across three compartments without adjustment.
Study record
| Study model | Human observational |
|---|---|
| Substance studied | Endogenous MOTS-c measuredNaturally occurring MOTS-c was measured; nothing was given. |
| Species | human |
| System studied | Stable peritoneal dialysis patients; MOTS-c measured in serum, urine and peritoneal dialysate |
| Population | adults on stable peritoneal dialysis |
| Design | Cross-sectional pilot study |
| Sample size as reported | 32 peritoneal dialysis patients |
| Control group | Not reported |
| Route (data field only) | Not reported |
| Endpoints measured | serum, urinary and dialysate MOTS-c; advanced oxidation protein products; carotid-femoral pulse wave velocity; left ventricular systolic function; blood pressure |
| Pathways measured | Oxidative stress |
| Research areas | Kidney · Cardiovascular · Mitochondrial biology |
| Evidence tier | B — Other human study |
| Publication types | Journal Article |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Direct
- Model applicability
- Human
- Sample size
- Small
- Controls
- None
- Outcome validity
- Validated biomarker
- Support for its own conclusion
- Weak
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.