Study record
The Association Between Serum MOTS-c Levels and Myocardial Ischemia-Reperfusion Injury in Patients with Acute Myocardial Infarction: A Cross-Sectional Study
Peng L, Li Y, Duan X et al. · Biomedicines · 2026
Human obs.Endogenous MOTS-c measuredEvidence tier B
What this study reported
Measured lower postoperative peripheral serum MOTS-c in patients with myocardial ischemia-reperfusion injury than in those without, while preoperative peripheral and intracoronary levels did not differ. Reported that postoperative peripheral MOTS-c was an independent factor in multivariable regression, with an area under the curve of 0.648 for discriminating injury.
Limitations
Small single-centre cross-sectional sample; modest discrimination; no longitudinal or repeated sampling, and residual confounding by procedural factors is likely.
Study record
| Study model | Human observational |
|---|---|
| Substance studied | Endogenous MOTS-c measuredNaturally occurring MOTS-c was measured; nothing was given. |
| Species | human |
| System studied | Patients with acute myocardial infarction undergoing percutaneous coronary intervention; peripheral and intracoronary serum MOTS-c |
| Population | adults with acute myocardial infarction undergoing percutaneous coronary intervention, with and without ischemia-reperfusion injury |
| Design | Cross-sectional study |
| Sample size as reported | 72 patients (34 with myocardial ischemia-reperfusion injury, 38 without) |
| Control group | patients without myocardial ischemia-reperfusion injury |
| Route (data field only) | Not reported |
| Endpoints measured | peripheral serum MOTS-c; intracoronary MOTS-c; occurrence of myocardial ischemia-reperfusion injury; TIMI grade and Killip class; ROC discrimination |
| Pathways measured | Other |
| Research areas | Cardiovascular · Mitochondrial biology |
| Evidence tier | B — Other human study |
| Publication types | Journal Article |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Direct
- Model applicability
- Human
- Sample size
- Small
- Controls
- Appropriate
- Outcome validity
- Validated biomarker
- Support for its own conclusion
- Moderate
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.