Study record
Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic Performance
Mendias CL, Awan TM · Sports Med · 2026
ReviewMOTS-c administeredEvidence tier R
What this study reported
Reviewed the mechanisms, reported safety information and regulatory status of a set of peptides marketed to patients, including MOTS-c, and noted that many unapproved peptides show tissue repair or metabolic outcomes in animal models while rigorous human data are scarce.
Limitations
Narrative review covering many compounds, so MOTS-c receives limited depth; no systematic search or quality grading of the underlying studies.
Study record
| Study model | Review |
|---|---|
| Substance studied | MOTS-c administeredSynthetic MOTS-c was given to cells, animals or people. |
| Species | Not reported |
| System studied | Narrative review of approved and unapproved peptides marketed in sports medicine, MOTS-c among them |
| Population | Not reported |
| Design | Narrative review |
| Sample size as reported | Not reported |
| Control group | Not reported |
| Route (data field only) | Not reported |
| Endpoints measured | pharmacological mechanisms; reported safety profiles; regulatory status |
| Pathways measured | Not reported |
| Research areas | Skeletal muscle · Exercise · Methods |
| Evidence tier | R — Review (context, not evidence) |
| Publication types | Journal Article, Review |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Peripheral
- Model applicability
- n/a
- Sample size
- n/a
- Controls
- n/a
- Outcome validity
- n/a
- Support for its own conclusion
- n/a
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.