Study record
Small but mighty: mitochondrial DNA at the centre of retrograde signalling
Harding E, Bazzani V, Vascotto C · Cell Commun Signal · 2026
ReviewRelated mitochondrial peptideEvidence tier R
What this study reported
Reviewed mitochondrial DNA as a signalling hub in retrograde communication with the nucleus, covering mitochondrial-derived non-coding RNAs and mitochondrial-derived peptides such as humanin, SHLPs and MOTS-c as messengers that reshape nuclear gene expression.
Limitations
Narrative review without systematic search or quality appraisal; MOTS-c is discussed only as one of several messengers rather than analysed in depth.
Study record
| Study model | Review |
|---|---|
| Substance studied | Related mitochondrial peptideThe paper is mainly about another mitochondrial-derived peptide, such as humanin. |
| Species | Not reported |
| System studied | Narrative review of mitochondrial DNA-driven retrograde signalling, including mitochondrial-derived peptides |
| Population | Not reported |
| Design | Narrative review |
| Sample size as reported | Not reported |
| Control group | Not reported |
| Route (data field only) | Not reported |
| Endpoints measured | mito-nuclear retrograde signalling mechanisms; mitochondrial-derived non-coding RNAs; mitochondrial-derived peptides including MOTS-c |
| Pathways measured | Nuclear translocation · Other |
| Research areas | Mitochondrial biology |
| Evidence tier | R — Review (context, not evidence) |
| Publication types | Journal Article, Review |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Peripheral
- Model applicability
- n/a
- Sample size
- n/a
- Controls
- n/a
- Outcome validity
- n/a
- Support for its own conclusion
- n/a
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.