Study record
Effects of graviola oil extract on fattening performance and circadian rhythms of adipokine, cardiac and mitochondrial function markers in lambs
Kotan GC, Bayraktar B · BMC Vet Res · 2026
AnimalEndogenous MOTS-c measuredEvidence tier C
What this study reported
Measured serum MOTS-c as one of several circadian biomarkers in lambs fed a graviola oil extract, and reported that the mid-level supplementation group showed modulated MOTS-c, BMAL1 and BMCP1 profiles with a peak at 19:00. Reported increases in live weight gain in that group relative to unsupplemented lambs.
Limitations
MOTS-c was a secondary ELISA biomarker rather than the study's subject; male lambs only; no mechanistic or tissue-level measurement of MOTS-c.
Study record
| Study model | Animal study (in vivo) |
|---|---|
| Substance studied | Endogenous MOTS-c measuredNaturally occurring MOTS-c was measured; nothing was given. |
| Species | sheep |
| System studied | Male Anatolian Merino lambs fed graviola oil extract; serum biomarker panel including MOTS-c |
| Population | Not reported |
| Design | Controlled animal feeding trial with circadian sampling |
| Sample size as reported | 48 male Anatolian Merino lambs |
| Control group | unsupplemented control group (G0) |
| Route (data field only) | Not reported |
| Endpoints measured | live weight and weight gain; feed conversion ratio; serum MOTS-c; serum BMAL1 and BMCP1; serum apelin and cardiac troponin I |
| Pathways measured | Other |
| Research areas | Metabolic · Mitochondrial biology · Cardiovascular |
| Evidence tier | C — Animal in vivo |
| Publication types | Journal Article |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Peripheral
- Model applicability
- Mammalian
- Sample size
- Adequate
- Controls
- Appropriate
- Outcome validity
- Exploratory
- Support for its own conclusion
- Weak
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.