Study record
Mitochondria-derived peptide MOTS-c alleviates hyperoxia-induced bronchopulmonary dysplasia in neonatal mice by activating Nrf2 pathway
Chen D, Zhou MH, Zhu WY et al. · Eur J Pharmacol · 2026
What this study reported
Measured lower MOTS-c content in neonatal mice with hyperoxia-induced bronchopulmonary dysplasia, and reported that administered MOTS-c was associated with less alveolar simplification, fewer pulmonary vascular abnormalities and less growth retardation. Reported that these effects, and the increases in endothelial cell viability and tube formation in human umbilical vein endothelial cells, were lost with an Nrf2 inhibitor or in Nrf2-deficient mice.
Limitations
Group sizes not reported in the abstract; male mice indexed in the record only; a single hyperoxia model with short-term endpoints and one endothelial cell type in vitro.
Study record
| Study model | Animal study (in vivo) |
|---|---|
| Substance studied | SeveralMore than one of these is central to the paper (common for reviews). |
| Species | mouse, human |
| System studied | Hyperoxia-exposed neonatal mice, including Nrf2-deficient mice, and hyperoxia-stimulated human umbilical vein endothelial cells |
| Population | Not reported |
| Design | Controlled animal experiment with cell culture experiments |
| Sample size as reported | not reported |
| Control group | vehicle-treated hyperoxia-exposed mice and normoxia controls |
| Route (data field only) | other |
| Endpoints measured | alveolar simplification; pulmonary vascular development; growth retardation; inflammation and oxidative stress markers; endothelial cell viability and tube formation; Nrf2 pathway activity |
| Pathways measured | NRF2 / antioxidant response · Oxidative stress · Inflammation |
| Research areas | Lung · Mitochondrial biology · Inflammation & immunity |
| Evidence tier | C — Animal in vivo |
| Publication types | Journal Article |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Direct
- Model applicability
- Mammalian
- Sample size
- Not reported
- Controls
- Appropriate
- Outcome validity
- Surrogate
- Support for its own conclusion
- Moderate
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.