Mitochondrial-derived microproteins in lung disease: insights and implications

What this study reported

Reviewed published work on mitochondrial-derived microproteins, noting that most of it concerns MOTS-c and humanin in high-mitochondrial-density tissues and in age-related disease rather than in the lung. Summarised reported mitochondrial, nuclear and extracellular actions of these peptides and how their levels have been reported to change across disease states. Identified gaps in the literature on acute lung injury, chronic obstructive pulmonary disease, allergic asthma and pulmonary fibrosis.

Limitations

Narrative review with no stated search strategy, largely a gap analysis because little primary pulmonary data on MOTS-c exists, and MOTS-c is discussed alongside other microproteins rather than appraised on its own.