Study record
Mitochondria-derived peptides in liver disease: Emerging regulators of hepatic metabolism and therapeutic targets
Thoudam T, Zeng G, Gao H et al. · Hepatol Commun · 2026
What this study reported
Reviewed published evidence on mitochondria-derived peptides in liver homeostasis and chronic liver disease, covering MOTS-c, humanin and small humanin-like peptides. Summarised reports that MOTS-c activates AMPK, regulates nuclear gene expression, suppresses fibrotic and inflammatory signalling and restores mitochondrial function in models of metabolic dysfunction-associated steatotic liver disease and fibrosis. Described proposed autocrine, paracrine and endocrine actions of these peptides.
Limitations
Narrative review without a stated search strategy or quality appraisal, summarising mainly cell and rodent models of liver disease, with MOTS-c one of several peptides discussed.
Study record
| Study model | Review |
|---|---|
| Substance studied | SeveralMore than one of these is central to the paper (common for reviews). |
| Species | Not reported |
| System studied | Published literature on mitochondria-derived peptides in liver homeostasis and chronic liver disease |
| Population | Not reported |
| Design | Narrative review |
| Sample size as reported | Not reported |
| Control group | Not reported |
| Route (data field only) | Not reported |
| Endpoints measured | reported roles of MOTS-c, humanin and SHLPs in hepatic metabolism; AMPK activation and nuclear gene regulation; fibrotic and inflammatory signalling in MASLD models; mitochondrial function, oxidative stress and apoptosis in hepatocytes |
| Pathways measured | AMPK signalling · Nuclear translocation · Inflammation · TGF-β / SMAD · Lipid metabolism · Apoptosis |
| Research areas | Liver · Metabolic · Mitochondrial biology |
| Evidence tier | R — Review (context, not evidence) |
| Publication types | Journal Article, Review |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Direct
- Model applicability
- n/a
- Sample size
- n/a
- Controls
- n/a
- Outcome validity
- n/a
- Support for its own conclusion
- Weak
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.