Study record
Serum Mitochondrial Open Reading Frame of the 12S rRNA-c (MOTS-c) Dynamics as a Complementary Marker of Treatment Response in Newly Diagnosed Multiple Myeloma: A Prospective Analysis
Erol V, Avci E, Kabukcu Hacioglu S et al. · Cureus · 2025
What this study reported
Measured serum MOTS-c before and after frontline treatment in adults with newly diagnosed multiple myeloma and reported a substantial post-treatment increase in responders, with little or no change in refractory cases. Found that post-treatment MOTS-c values correlated inversely with changes in calcium and neutrophil count. Reported limited standalone predictive capacity for MOTS-c in this cohort.
Limitations
Small single-cohort sample of 29 patients with no untreated comparison group, heterogeneous frontline regimens, and exploratory correlational analyses without adjustment or external validation.
Study record
| Study model | Human observational |
|---|---|
| Substance studied | Endogenous MOTS-c measuredNaturally occurring MOTS-c was measured; nothing was given. |
| Species | human |
| System studied | Patients newly diagnosed with multiple myeloma sampled before and after frontline treatment |
| Population | adults newly diagnosed with multiple myeloma |
| Design | Prospective single-arm cohort with paired pre- and post-treatment sampling |
| Sample size as reported | 29 patients with multiple myeloma |
| Control group | Not reported |
| Route (data field only) | Not reported |
| Endpoints measured | serum MOTS-c concentration; treatment response status; serum calcium; neutrophil count |
| Pathways measured | Not reported |
| Research areas | Cancer · Mitochondrial biology |
| Evidence tier | B — Other human study |
| Publication types | Journal Article |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Direct
- Model applicability
- Human
- Sample size
- Small
- Controls
- None
- Outcome validity
- Exploratory
- Support for its own conclusion
- Weak
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.