Study record
Circulating Mitochondrial Open Reading Frame of the 12S Ribosomal RNA Type-c Is Higher in Acute Coronary Syndrome and Is a Prognostic Biomarker for Major Cardiac Events in Patients With Acute Myocardial Infarction: A Case-Control Study
Cao P, Wang B, Zhang N et al. · J Am Heart Assoc · 2025
What this study reported
Reported higher serum MOTS-c and thiobarbituric acid reactive substances in patients with acute coronary syndrome than in controls, with a positive correlation between the two. Found that the ratio of MOTS-c to thiobarbituric acid reactive substances discriminated patients who went on to have major adverse cardiac events over 18 months of follow-up in the acute myocardial infarction group. Reported in cultured cells that oxidative stress raised MOTS-c levels and that MOTS-c exposure lowered hypoxia-induced oxidative stress.
Limitations
Single-timepoint admission sampling in one recruited cohort with no external validation of the reported cut-off values, modest discrimination statistics, and in vitro work in an unspecified cell system reported only in summary.
Study record
| Study model | Human observational |
|---|---|
| Substance studied | SeveralMore than one of these is central to the paper (common for reviews). |
| Species | human |
| System studied | Patients with unstable angina or acute myocardial infarction and normal controls; cultured cells under hypoxia |
| Population | adults with acute coronary syndrome (unstable angina or acute myocardial infarction) and normal controls |
| Design | Case-control study with 18-month follow-up and accompanying cell culture experiments |
| Sample size as reported | 400 subjects in three groups (normal controls, unstable angina, acute myocardial infarction) |
| Control group | normal controls without acute coronary syndrome |
| Route (data field only) | in-culture |
| Endpoints measured | serum MOTS-c levels; thiobarbituric acid reactive substances; major adverse cardiac events; diagnostic discrimination (ROC area under the curve); hypoxia-induced oxidative stress in cells |
| Pathways measured | Oxidative stress |
| Research areas | Cardiovascular · Mitochondrial biology |
| Evidence tier | B — Other human study |
| Publication types | Journal Article, Research Support, Non-U.S. Gov't |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Direct
- Model applicability
- Human
- Sample size
- Adequate
- Controls
- Appropriate
- Outcome validity
- Clinical outcome
- Support for its own conclusion
- Moderate
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.