Study record
MOTS-C levels ın ındividuals with and without obesity and ıts association with ınflammation, insulin resistance and endothelial dysfunction
Ozkaya DY, Haymana C, Demirci I et al. · Arch Endocrinol Metab · 2025
What this study reported
Measured serum MOTS-c in adults with and without obesity and found no significant difference between the groups. Reported a positive correlation between serum MOTS-c and HOMA-IR but no correlation with high-sensitivity C-reactive protein or asymmetric dimethylarginine, and found in multiple regression that MOTS-c was lower with older age and higher with greater insulin resistance in these participants.
Limitations
Small single-centre cross-sectional sample with unequal groups and no longitudinal data; broad exclusions limit generalisability, endothelial function was assessed only by a single circulating marker, and the null primary comparison may be underpowered.
Study record
| Study model | Human observational |
|---|---|
| Substance studied | Endogenous MOTS-c measuredNaturally occurring MOTS-c was measured; nothing was given. |
| Species | human |
| System studied | Adults with obesity and adults with normal body mass index, sampled after an overnight fast |
| Population | adults with obesity and adults with normal body mass index, excluding smokers, pregnancy and type 2 diabetes |
| Design | Cross-sectional comparative study |
| Sample size as reported | 85 individuals (48 with BMI >= 30, 37 with BMI 18.5-24.9) |
| Control group | 37 individuals with normal body mass index |
| Route (data field only) | Not reported |
| Endpoints measured | serum MOTS-c; HOMA-IR; serum insulin; high-sensitivity C-reactive protein; asymmetric dimethylarginine |
| Pathways measured | Insulin & glucose handling · Inflammation |
| Research areas | Metabolic · Cardiovascular |
| Evidence tier | B — Other human study |
| Publication types | Journal Article |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Direct
- Model applicability
- Human
- Sample size
- Small
- Controls
- Appropriate
- Outcome validity
- Surrogate
- Support for its own conclusion
- Moderate
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.