Study record
Exercise-Induced Muscle-Fat Crosstalk: Molecular Mediators and Their Pharmacological Modulation for the Maintenance of Metabolic Flexibility in Aging
Tero-Vescan A, Degens H, Matsakas A et al. · Pharmaceuticals (Basel) · 2025
What this study reported
Reviewed reported mechanisms of exercise-induced crosstalk between skeletal muscle and adipose tissue, including IL-6, irisin, leptin and adiponectin, and AMPK, PGC-1α, SIRT1 and PI3K/Akt/mTOR signalling. Described MOTS-c among emerging exercise mimetics discussed in relation to muscle mass, browning of white adipose tissue and systemic metabolic function, and proposed a stratified framework for age-related comorbidities.
Limitations
Narrative review with no stated search strategy or appraisal of the cited studies; MOTS-c is mentioned only briefly among many mediators, and the proposed treatment algorithm is not derived from pooled or graded evidence.
Study record
| Study model | Review |
|---|---|
| Substance studied | SeveralMore than one of these is central to the paper (common for reviews). |
| Species | Not reported |
| System studied | Narrative review of exercise-induced muscle-adipose crosstalk and candidate exercise mimetics, including MOTS-c |
| Population | Not reported |
| Design | Narrative review |
| Sample size as reported | Not reported |
| Control group | Not reported |
| Route (data field only) | Not reported |
| Endpoints measured | myokine and adipokine signalling; mitochondrial biogenesis; fatty acid oxidation; muscle hypertrophy signalling; metabolic flexibility |
| Pathways measured | AMPK signalling · SIRT1 / PGC-1α / biogenesis · AKT / mTOR / FOXO · Thermogenesis / brown fat · Lipid metabolism · Inflammation |
| Research areas | Exercise · Metabolic · Aging · Skeletal muscle |
| Evidence tier | R — Review (context, not evidence) |
| Publication types | Journal Article, Review |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Peripheral
- Model applicability
- n/a
- Sample size
- n/a
- Controls
- n/a
- Outcome validity
- n/a
- Support for its own conclusion
- Weak
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.