Study record
A mitochondrial-derived peptide MOTS-c contributes to the protective effect against brain injury associated with LPS-induced sepsis by strengthening the blood-brain barrier's ultrastructure
Bai Y, Wu H, Wang X et al. · Int J Neurosci · 2026
What this study reported
Reported that administered MOTS-c was associated with higher survival and lower murine sepsis scores in mice with lipopolysaccharide-induced sepsis. Found less histological brain tissue damage, lower expression of inflammatory factors and of GFAP, Iba-1 and MMP-9, and reduced blood-brain barrier permeability in these mice. Reported higher expression of blood-brain barrier-related proteins, CD31/PDGFRβ and neurotrophic factors in the same model.
Limitations
Single mouse strain and males only, a single lipopolysaccharide sepsis model with group sizes not reported in the abstract, surrogate barrier and expression endpoints, and no reported blinding of outcome assessment.
Study record
| Study model | Animal study (in vivo) |
|---|---|
| Substance studied | MOTS-c administeredSynthetic MOTS-c was given to cells, animals or people. |
| Species | mouse |
| System studied | Male C57BL/6 mice with lipopolysaccharide-induced sepsis, in four groups with and without MOTS-c |
| Population | Not reported |
| Design | Controlled animal experiment |
| Sample size as reported | Not reported |
| Control group | control mice and lipopolysaccharide-only mice without MOTS-c |
| Route (data field only) | Not reported |
| Endpoints measured | survival rate and murine sepsis score; brain tissue damage on histology; inflammatory factor expression; blood-brain barrier permeability and water content; blood-brain barrier and neurotrophic protein expression |
| Pathways measured | Inflammation |
| Research areas | Nervous system · Inflammation & immunity |
| Evidence tier | C — Animal in vivo |
| Publication types | Journal Article |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Direct
- Model applicability
- Mammalian
- Sample size
- Not reported
- Controls
- Appropriate
- Outcome validity
- Surrogate
- Support for its own conclusion
- Moderate
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.