Study record
Mitochondrial-Derived Peptides: Implication in the Therapy of Neurodegenerative Diseases
Thakur R, Chauhan A, Moudgil H et al. · Mol Neurobiol · 2025
What this study reported
Reviewed literature retrieved from PubMed, Scopus and Web of Science on mitochondrial-derived peptides including humanin, MOTS-c and small humanin-like peptides in models of Alzheimer's, Parkinson's and Huntington's disease. Summarised reported effects on mitochondrial function, oxidative stress and neuroinflammation in those models and noted that molecular pathways, targeted delivery and clinical translation remain poorly characterised.
Limitations
Describes a keyword search but reports no formal eligibility criteria, data extraction or quality appraisal; MOTS-c is one of several peptides covered and the included evidence is largely preclinical.
Study record
| Study model | Review |
|---|---|
| Substance studied | SeveralMore than one of these is central to the paper (common for reviews). |
| Species | Not reported |
| System studied | Review of mitochondrial-derived peptides (humanin, MOTS-c, SHLPs) in Alzheimer's, Parkinson's and Huntington's disease models |
| Population | Not reported |
| Design | Literature review with stated database search |
| Sample size as reported | Not reported |
| Control group | Not reported |
| Route (data field only) | Not reported |
| Endpoints measured | mitochondrial function; oxidative stress; neuroinflammation; amyloid-beta toxicity; dopaminergic neuron loss; mutant huntingtin aggregation |
| Pathways measured | Oxidative stress · Inflammation |
| Research areas | Nervous system · Mitochondrial biology |
| Evidence tier | R — Review (context, not evidence) |
| Publication types | Journal Article, Review |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Indirect
- Model applicability
- n/a
- Sample size
- n/a
- Controls
- n/a
- Outcome validity
- n/a
- Support for its own conclusion
- Weak
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.