The unexplored Nexus: Mitochondria derived microproteins and Parkinson's disease

What this study reported

Reviewed the literature on mitochondria-derived microproteins, including humanin, small humanin-like peptides and MOTS-c, in relation to Parkinson's disease pathogenesis. Summarised their reported involvement in mitochondrial dysfunction, oxidative stress, neuroinflammation and impaired autophagy across cell and animal models, and identified them as candidate targets for further mechanistic research.

Limitations

Narrative review with no stated search strategy, inclusion criteria or risk-of-bias assessment; MOTS-c is covered only as one of several peptides and the underlying evidence is preclinical.