Study record
Mitochondrial-Derived Peptides as Therapeutics and Biomarkers for Combating Vascular Aging and Associated Cardiovascular Diseases
Sivakumar R, Aravaanan ASK, Mohanakrishnan VV et al. · Curr Cardiol Rev · 2026
What this study reported
Reviewed published work on mitochondrial-derived peptides, including MOTS-c, humanin and small humanin-like peptides, in relation to vascular aging and age-related cardiovascular disease. Summarised reported effects on apoptosis, inflammation and oxidative stress in endothelial and vascular smooth muscle cells, and on AMPK, mTOR and sirtuin signalling. Described proposed biomarker and intervention applications and called for further study.
Limitations
Narrative review without a stated search strategy or inclusion criteria, drawing on heterogeneous preclinical sources, and MOTS-c is covered as one of several peptides rather than appraised separately.
Study record
| Study model | Review |
|---|---|
| Substance studied | SeveralMore than one of these is central to the paper (common for reviews). |
| Species | Not reported |
| System studied | Published literature on mitochondrial-derived peptides in vascular aging and cardiovascular disease |
| Population | Not reported |
| Design | Narrative review |
| Sample size as reported | Not reported |
| Control group | Not reported |
| Route (data field only) | Not reported |
| Endpoints measured | reported roles of MOTS-c, humanin and small humanin-like peptides in vascular aging; endothelial and vascular smooth muscle cell function; AMPK, mTOR and sirtuin signalling; biomarker proposals |
| Pathways measured | AMPK signalling · AKT / mTOR / FOXO · SIRT1 / PGC-1α / biogenesis · Oxidative stress · Inflammation · Apoptosis |
| Research areas | Cardiovascular · Aging · Mitochondrial biology |
| Evidence tier | R — Review (context, not evidence) |
| Publication types | Journal Article, Review |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Indirect
- Model applicability
- n/a
- Sample size
- n/a
- Controls
- n/a
- Outcome validity
- n/a
- Support for its own conclusion
- Weak
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.