Study record
MOTS-c modulates pancreatic islet function in rats and pigs in vitro
Bień J, Pruszynska-Oszmalek E, Kolodziejski P et al. · Histochem Cell Biol · 2025
What this study reported
Reported that MOTS-c exposure was associated with reduced insulin and glucagon secretion and greater cell viability in isolated rat and pig pancreatic islets. Found that the responses differed between the two species, which the authors attributed to islet anatomy or sequence differences, and that MOTS-c secretion varied with free fatty acids, pancreatic hormones and glucose in the incubation medium.
Limitations
Isolated islets removed from systemic regulation; numbers of donors and islet preparations are not reported in the abstract; male animals and short-term culture only, with no in vivo confirmation.
Study record
| Study model | Tissue / sample study (ex vivo) |
|---|---|
| Substance studied | MOTS-c administeredSynthetic MOTS-c was given to cells, animals or people. |
| Species | rat, pig |
| System studied | Isolated pancreatic islets from rats (Wistar and Sprague-Dawley) and pigs, incubated in culture |
| Population | Not reported |
| Design | Ex vivo isolated-islet culture experiments in two species |
| Sample size as reported | not reported |
| Control group | Untreated islets incubated in parallel |
| Route (data field only) | in-culture |
| Endpoints measured | insulin secretion and expression; glucagon secretion and expression; insulin and glucagon receptor expression; islet cell viability; cell death; MOTS-c secretion under different incubation media |
| Pathways measured | Insulin & glucose handling |
| Research areas | Metabolic · Mitochondrial biology |
| Evidence tier | D — Cell, tissue or analytical |
| Publication types | Journal Article |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Direct
- Model applicability
- Cellular
- Sample size
- Not reported
- Controls
- Appropriate
- Outcome validity
- Surrogate
- Support for its own conclusion
- Moderate
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.