Study record
Circulating mitochondrial biomarkers in acute coronary syndrome
Iboleon-Jimenez A, Sánchez-Quintero MJ, Carmona-Segovia ADM et al. · Front Med (Lausanne) · 2025
Human obs.Endogenous MOTS-c measuredEvidence tier B
What this study reported
Found lower plasma MOTS-c and PGC-1α in adults with acute coronary syndrome than in controls, with no significant effect of sex on either marker. Reported that MOTS-c correlated positively with first troponin and haemoglobin in this cohort.
Limitations
Very small case-control sample with few participants per sex subgroup, limiting the sex-interaction analysis; single-timepoint measurement with multiple unadjusted correlations.
Study record
| Study model | Human observational |
|---|---|
| Substance studied | Endogenous MOTS-c measuredNaturally occurring MOTS-c was measured; nothing was given. |
| Species | human |
| System studied | Patients admitted with acute coronary syndrome and healthy controls, sampled after an overnight fast |
| Population | Adults with acute coronary syndrome and controls, analysed by sex |
| Design | Case-control study with sex as a factor |
| Sample size as reported | 38 participants (18 ACS patients: 8 women, 10 men; 20 controls: 8 women, 12 men) |
| Control group | 20 controls without acute coronary syndrome |
| Route (data field only) | Not reported |
| Endpoints measured | plasma MOTS-c; plasma PGC-1α; plasma citrate synthase; troponin; NT-proBNP and C-reactive protein |
| Pathways measured | SIRT1 / PGC-1α / biogenesis |
| Research areas | Cardiovascular · Mitochondrial biology |
| Evidence tier | B — Other human study |
| Publication types | Journal Article |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Direct
- Model applicability
- Human
- Sample size
- Small
- Controls
- Appropriate
- Outcome validity
- Exploratory
- Support for its own conclusion
- Moderate
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.