Study record
MOTS-c as a Potential Diagnostic-prognostic Biomarker for Myocardial Infarction
Cakmak A, Yazgan B · Cardiovasc Hematol Agents Med Chem · 2025
What this study reported
Measured serum MOTS-c by ELISA and found no significant difference between adults with myocardial infarction and angiography-negative controls, while reporting changes in MOTS-c across days 0, 3 and 30 within the infarction group. Found a negative correlation between MOTS-c and platelet count at day 0 and between MOTS-c and troponin I at day 3 in the infarction group.
Limitations
Group sizes are not reported in the abstract and appear small given correlation p values near 0.05; correlational single-centre design with multiple unadjusted comparisons and no clinical outcome follow-up.
Study record
| Study model | Human observational |
|---|---|
| Substance studied | Endogenous MOTS-c measuredNaturally occurring MOTS-c was measured; nothing was given. |
| Species | human |
| System studied | Patients with angiographically confirmed obstructive coronary lesions and myocardial infarction, and angiography-negative controls |
| Population | Adults with myocardial infarction and significant obstructive coronary lesions, compared with patients without obstructive lesions on angiography |
| Design | Case-control study with repeated serum sampling |
| Sample size as reported | not reported |
| Control group | Patients without obstructive coronary lesions on angiography |
| Route (data field only) | Not reported |
| Endpoints measured | serum MOTS-c; troponin I; C-reactive protein; erythrocyte sedimentation rate; platelet count |
| Pathways measured | Not reported |
| Research areas | Cardiovascular · Mitochondrial biology |
| Evidence tier | B — Other human study |
| Publication types | Journal Article |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Direct
- Model applicability
- Human
- Sample size
- Not reported
- Controls
- Limited
- Outcome validity
- Exploratory
- Support for its own conclusion
- Weak
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.