Study record
Mitochondria‑derived peptides: Promising microproteins in cardiovascular diseases (Review)
Ran Y, Guo Z, Zhang L et al. · Mol Med Rep · 2025
ReviewSeveralEvidence tier R
What this study reported
Reviewed published work on mitochondrial-derived peptides, including MOTS-c and humanin, and described reported associations with mitochondrial function, oxidative damage and inflammation in cardiovascular disease. Noted that low bioavailability, poor stability and synthesis cost were described as obstacles to clinical study.
Limitations
Narrative review with no stated search strategy or risk-of-bias appraisal; aggregates heterogeneous cell, animal and human reports without quantitative synthesis.
Study record
| Study model | Review |
|---|---|
| Substance studied | SeveralMore than one of these is central to the paper (common for reviews). |
| Species | Not reported |
| System studied | Narrative review of mitochondrial-derived peptides, including MOTS-c and humanin, in cardiovascular disease |
| Population | Not reported |
| Design | Narrative review |
| Sample size as reported | Not reported |
| Control group | Not reported |
| Route (data field only) | Not reported |
| Endpoints measured | mitochondrial function; oxidative damage; inflammation; cardiovascular disease mechanisms |
| Pathways measured | Oxidative stress · Inflammation · Other |
| Research areas | Cardiovascular · Mitochondrial biology |
| Evidence tier | R — Review (context, not evidence) |
| Publication types | Journal Article, Review |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Direct
- Model applicability
- n/a
- Sample size
- n/a
- Controls
- n/a
- Outcome validity
- n/a
- Support for its own conclusion
- Weak
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.