Study record
MOTS-c mimics remote ischemic preconditioning in protecting against lung ischemia-reperfusion injury by alleviating endothelial barrier dysfunction
Wang DD, Xu B, Sun JJ et al. · Free Radic Biol Med · 2025
What this study reported
Measured lower serum MOTS-c after ischemia-reperfusion injury in lung transplantation patients and higher levels when remote ischemic preconditioning preceded transplantation. In mice and endothelial cells, administered MOTS-c was associated with reduced lung injury and preserved endothelial barrier integrity through higher Nrf2 levels, with effects lost in Nrf2 knockout mice and with an Nrf2 inhibitor.
Limitations
Human sample sizes are not reported and the clinical measurements are observational; animal work uses male mice in a single injury model; cell work relies on one endothelial line.
Study record
| Study model | Human observational |
|---|---|
| Substance studied | SeveralMore than one of these is central to the paper (common for reviews). |
| Species | human, mouse |
| System studied | Serum MOTS-c in lung transplantation patients with and without remote ischemic preconditioning, a mouse lung ischemia-reperfusion model, and HUVEC and skeletal muscle cell cultures |
| Population | patients undergoing lung transplantation, with or without remote ischemic preconditioning |
| Design | Clinical sample measurement with animal and cell experiments |
| Sample size as reported | Not reported |
| Control group | patients and mice without remote ischemic preconditioning; untreated cells; Nrf2 knockout mice |
| Route (data field only) | intravenous |
| Endpoints measured | serum MOTS-c; lung injury severity; endothelial barrier function; Nrf2 protein levels |
| Pathways measured | NRF2 / antioxidant response · Oxidative stress |
| Research areas | Lung · Cardiovascular |
| Evidence tier | B — Other human study |
| Publication types | Journal Article |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Direct
- Model applicability
- Human
- Sample size
- Not reported
- Controls
- Appropriate
- Outcome validity
- Surrogate
- Support for its own conclusion
- Moderate
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.