Study record
Evaluation of vascular peroxidase 1, humanin, MOTS-c and miR-200c expression levels in untreated preeclampsia patients
Coskun E, Ekmekci OB, Gungor Z et al. · Mol Biol Rep · 2024
Human obs.Endogenous MOTS-c measuredEvidence tier B
What this study reported
Measured lower serum MOTS-c in women with untreated preeclampsia than in controls, alongside higher endoglin, VPO1 and miR-200c and no significant difference in humanin.
Limitations
Sample sizes are not reported and blood was sampled at one time point before treatment; correlations cannot establish direction; the MOTS-c result differs from other preeclampsia reports.
Study record
| Study model | Human observational |
|---|---|
| Substance studied | Endogenous MOTS-c measuredNaturally occurring MOTS-c was measured; nothing was given. |
| Species | human |
| System studied | Serum endoglin, VPO1, humanin, MOTS-c and miR-200c in untreated preeclamptic pregnancies and control pregnancies |
| Population | pregnant women with untreated preeclampsia and control pregnant women |
| Design | Case-control study |
| Sample size as reported | Not reported |
| Control group | control pregnant women |
| Route (data field only) | Not reported |
| Endpoints measured | serum MOTS-c; serum humanin; VPO1; endoglin; miR-200c |
| Pathways measured | Oxidative stress |
| Research areas | Pregnancy · Cardiovascular |
| Evidence tier | B — Other human study |
| Publication types | Journal Article |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Direct
- Model applicability
- Human
- Sample size
- Not reported
- Controls
- Appropriate
- Outcome validity
- Exploratory
- Support for its own conclusion
- Moderate
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.