Study record
MOTS-c regulates the ROS/TXNIP/NLRP3 pathway to alleviate diabetic cardiomyopathy
Fu Y, Tang M, Duan Y et al. · Biochem Biophys Res Commun · 2024
AnimalMOTS-c administeredEvidence tier C
What this study reported
Reported that administered MOTS-c was associated with lower ROS/TXNIP/NLRP3 pathway protein expression and less myocardial inflammatory change in rats with diet- and streptozotocin-induced diabetes.
Limitations
Single rat strain, males only, with group sizes and blinding not reported; readouts are protein markers and histology rather than cardiac function measures.
Study record
| Study model | Animal study (in vivo) |
|---|---|
| Substance studied | MOTS-c administeredSynthetic MOTS-c was given to cells, animals or people. |
| Species | rat |
| System studied | Male Sprague-Dawley rats with high-sugar-fat diet and streptozotocin-induced diabetes |
| Population | Not reported |
| Design | Controlled animal experiment |
| Sample size as reported | Not reported |
| Control group | diabetic rats not given MOTS-c |
| Route (data field only) | intraperitoneal |
| Endpoints measured | cardiac structure; reactive oxygen species; TXNIP; NLRP3 inflammasome proteins; myocardial inflammatory markers |
| Pathways measured | Inflammation · Oxidative stress |
| Research areas | Cardiovascular · Metabolic |
| Evidence tier | C — Animal in vivo |
| Publication types | Journal Article, Research Support, Non-U.S. Gov't |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Direct
- Model applicability
- Mammalian
- Sample size
- Not reported
- Controls
- Appropriate
- Outcome validity
- Surrogate
- Support for its own conclusion
- Moderate
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.