Study record
The Human Mitochondrial Genome Encodes for an Interferon-Responsive Host Defense Peptide
Rice MC, Imun M, Jung SW et al. · bioRxiv · 2024
CellsSeveralEvidence tier DAlso: Analytical / methods
What this study reported
Reported that MOTS-c is an amphipathic cationic peptide with antibacterial activity against E. coli and methicillin-resistant S. aureus in culture, apparently through membrane targeting. Also reported that IFNγ, LPS and differentiation signals induced endogenous MOTS-c in monocytes and that MOTS-c translocated to the nucleus and shifted macrophage transcriptional programmes.
Limitations
Preprint that has not been peer reviewed; bacterial and cell culture assays only, with no animal or human infection data; replicate numbers are not reported.
Study record
| Study model | Cell study (in vitro) |
|---|---|
| Substance studied | SeveralMore than one of these is central to the paper (common for reviews). |
| Species | human |
| System studied | Bacterial cultures of E. coli and methicillin-resistant S. aureus and human monocytes differentiating into macrophages |
| Population | Not reported |
| Design | Cell culture and antibacterial assay experiments (preprint) |
| Sample size as reported | Not reported |
| Control group | untreated bacterial cultures and undifferentiated monocytes |
| Route (data field only) | in-culture |
| Endpoints measured | bacterial killing; endogenous MOTS-c expression in monocytes; nuclear translocation; macrophage transcriptome; bacterial clearance by macrophages |
| Pathways measured | Nuclear translocation · Inflammation |
| Research areas | Inflammation & immunity · Mitochondrial biology |
| Evidence tier | D — Cell, tissue or analytical |
| Publication types | Journal Article, Preprint |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Direct
- Model applicability
- Cellular
- Sample size
- Not reported
- Controls
- Appropriate
- Outcome validity
- Exploratory
- Support for its own conclusion
- Moderate
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.