Study record
The Relationship Between MOTS-c K14Q Polymorphism and Sarcopenia, Blood Lipids, and Mental Health in Older Korean Adults
Kim S · Biomedicines · 2024
Human obs.MT-RNR1 / K14Q variantEvidence tier B
What this study reported
Found higher appendicular skeletal muscle mass, lean mass and handgrip strength in older Korean men carrying the C allele than in A-allele carriers, with the differences persisting after covariate adjustment. No significant genotype differences were found in women or in blood lipids and mental health measures.
Limitations
Cross-sectional, single-ethnicity sample with few C-allele carriers; many outcomes tested; muscle mass estimated rather than imaged directly.
Study record
| Study model | Human observational |
|---|---|
| Substance studied | MT-RNR1 / K14Q variantStudies of the m.1382A>C (K14Q) variant or other MT-RNR1 variation. |
| Species | human |
| System studied | m.1382A>C (K14Q) genotype and sarcopenia measures in community-dwelling Korean adults aged 65 years and older |
| Population | 683 community-dwelling Korean adults aged 65 years and older |
| Design | Cross-sectional cohort |
| Sample size as reported | 683 adults (345 men, 338 women) |
| Control group | carriers of the A allele |
| Route (data field only) | Not reported |
| Endpoints measured | appendicular skeletal muscle mass; handgrip strength; lean mass; blood lipids; cognitive function and depression |
| Pathways measured | Not reported |
| Research areas | Aging · Skeletal muscle |
| Evidence tier | B — Other human study |
| Publication types | Journal Article |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Direct
- Model applicability
- Human
- Sample size
- Adequate
- Controls
- Appropriate
- Outcome validity
- Validated biomarker
- Support for its own conclusion
- Moderate
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.