Study record
Temporal expression of mitochondrial life cycle markers during acute and chronic overload of rat plantaris muscles
Hyatt JK, Lu EJ, McCall GE · Front Physiol · 2024
AnimalEndogenous MOTS-c measuredEvidence tier C
What this study reported
Measured higher mitochondrially encoded peptide expression, including MOTS-c, in rat plantaris muscle after 10 weeks of functional overload but not after 1 week, alongside sustained mitochondrial biogenesis markers and normalisation of early mitophagy and autophagy marker increases.
Limitations
Female rats only at two time points with group sizes and a comparison group not described in the abstract; MOTS-c is one of many markers measured and was not manipulated; surgical overload is not comparable to voluntary exercise.
Study record
| Study model | Animal study (in vivo) |
|---|---|
| Substance studied | Endogenous MOTS-c measuredNaturally occurring MOTS-c was measured; nothing was given. |
| Species | rat |
| System studied | Adult female rats after functional overload of the plantaris muscle, assessed at 1 and 10 weeks |
| Population | Not reported |
| Design | Controlled animal experiment |
| Sample size as reported | Not reported |
| Control group | Not reported |
| Route (data field only) | Not reported |
| Endpoints measured | plantaris muscle mass; myosin heavy chain isoforms; mitochondrial biogenesis markers; mitophagy and autophagy markers; OXPHOS proteins; humanin and MOTS-c expression |
| Pathways measured | SIRT1 / PGC-1α / biogenesis · Autophagy / mitophagy |
| Research areas | Skeletal muscle · Mitochondrial biology · Exercise |
| Evidence tier | C — Animal in vivo |
| Publication types | Journal Article |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Peripheral
- Model applicability
- Mammalian
- Sample size
- Not reported
- Controls
- Limited
- Outcome validity
- Surrogate
- Support for its own conclusion
- Moderate
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.