Study record
Mitochondria-encoded peptide MOTS-c participates in plasma membrane repair by facilitating the translocation of TRIM72 to membrane
Jia H, Zhou LC, Chen YF et al. · Theranostics · 2024
What this study reported
Measured MOTS-c levels in human participants that correlated positively with mitochondrial abundance and with TRIM72, with greater MOTS-c secretion after moderate-intensity than after high-intensity eccentric exercise. In cells and mice, MOTS-c was reported to promote TRIM72 trafficking to damaged membrane and to interact with phosphatidylinositol (4,5) bisphosphate, while having little membrane-repair effect on its own.
Limitations
Human sample size and characteristics are not reported and the human data are correlative; animal work relies on a single knockout line; the mix of models makes attribution of each finding difficult.
Study record
| Study model | Human observational |
|---|---|
| Substance studied | SeveralMore than one of these is central to the paper (common for reviews). |
| Species | human, mouse |
| System studied | Human participants after moderate-intensity or high-intensity eccentric exercise, TRIM72 knockout mice, and cultured muscle and endothelial cells |
| Population | human participants performing moderate-intensity or high-intensity eccentric exercise |
| Design | Exercise study with MOTS-c measured, plus animal and cell experiments |
| Sample size as reported | Not reported |
| Control group | high-intensity eccentric exercise comparison group; wild-type and TRIM72 knockout mice |
| Route (data field only) | Not reported |
| Endpoints measured | circulating MOTS-c; sarcolemma integrity; physical performance; MOTS-c and TRIM72 interaction; membrane repair in culture; cardiac function after ischemia-reperfusion |
| Pathways measured | Other |
| Research areas | Skeletal muscle · Exercise · Cardiovascular |
| Evidence tier | B — Other human study |
| Publication types | Journal Article, Research Support, Non-U.S. Gov't |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Direct
- Model applicability
- Human
- Sample size
- Not reported
- Controls
- Limited
- Outcome validity
- Surrogate
- Support for its own conclusion
- Moderate
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.