Study record
Pyrroloquinoline Quinone Alleviates Mitochondria Damage in Radiation-Induced Lung Injury in a MOTS-c-Dependent Manner
Zhang Y, Huang J, Li S et al. · J Agric Food Chem · 2024
AnimalEndogenous MOTS-c measuredEvidence tier CAlso: Cell study (in vitro)
What this study reported
Reported that pyrroloquinoline quinone was associated with less radiation-induced lung damage, oxidative stress, inflammation and apoptosis in mice and in MLE-12 cells, and measured higher MOTS-c mRNA and protein in irradiated lung tissue and cells after pyrroloquinoline quinone. MOTS-c knockdown by siRNA reduced these effects.
Limitations
Single irradiation model in male mice with group sizes not reported; MOTS-c involvement is shown only by siRNA knockdown in one cell line, and MOTS-c itself was not administered.
Study record
| Study model | Animal study (in vivo) |
|---|---|
| Substance studied | Endogenous MOTS-c measuredNaturally occurring MOTS-c was measured; nothing was given. |
| Species | mouse |
| System studied | C57BL/6 mice given oral pyrroloquinoline quinone after thoracic irradiation, plus MLE-12 lung epithelial cells |
| Population | Not reported |
| Design | Controlled animal experiment with cell culture experiments |
| Sample size as reported | Not reported |
| Control group | irradiated mice and cells without pyrroloquinoline quinone |
| Route (data field only) | Not reported |
| Endpoints measured | lung tissue damage; oxidative stress; inflammation; epithelial apoptosis; MOTS-c mRNA and protein |
| Pathways measured | Oxidative stress · Apoptosis · Inflammation |
| Research areas | Lung · Mitochondrial biology |
| Evidence tier | C — Animal in vivo |
| Publication types | Journal Article |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Indirect
- Model applicability
- Mammalian
- Sample size
- Not reported
- Controls
- Appropriate
- Outcome validity
- Surrogate
- Support for its own conclusion
- Moderate
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.