Study record
Expression Patterns of MOTS-c in Adrenal Tumors: Results from a Preliminary Study
Kamiński K, Blatkiewicz M, Szyszka M et al. · Int J Mol Sci · 2024
Human obs.Endogenous MOTS-c measuredEvidence tier B
What this study reported
Measured lower MOTS-c mRNA and lower tissue MOTS-c protein in all three adrenal tumour types than in control adrenal tissue, with higher serum MOTS-c in adenoma and pheochromocytoma but not carcinoma. Reported lower MOTS-c protein with advancing carcinoma stage and correlations of serum MOTS-c with glucose, cholesterol fractions and SHBG.
Limitations
Preliminary study with group sizes not reported and many correlations tested without a stated adjustment; cross-sectional tissue sampling cannot show direction of effect.
Study record
| Study model | Human observational |
|---|---|
| Substance studied | Endogenous MOTS-c measuredNaturally occurring MOTS-c was measured; nothing was given. |
| Species | human |
| System studied | MOTS-c mRNA, tissue protein and serum protein in adrenocortical carcinoma, adrenocortical adenoma and pheochromocytoma compared with normal adrenal tissue |
| Population | patients with adrenocortical carcinoma, adrenocortical adenoma or pheochromocytoma and controls with normal adrenal tissue |
| Design | Preliminary case-control tissue and serum study |
| Sample size as reported | Not reported |
| Control group | normal adrenal tissue and healthy controls |
| Route (data field only) | Not reported |
| Endpoints measured | MOTS-c mRNA expression; tissue MOTS-c protein; serum MOTS-c; correlations with tumour size, testosterone and lipids |
| Pathways measured | Not reported |
| Research areas | Cancer |
| Evidence tier | B — Other human study |
| Publication types | Journal Article |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Direct
- Model applicability
- Human
- Sample size
- Not reported
- Controls
- Appropriate
- Outcome validity
- Exploratory
- Support for its own conclusion
- Weak
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.