Study record
Effects of empagliflozin and dapagliflozin on serum humanin, MOTS-c levels, nitrosative stress, and ferroptosis parameters in diabetic patients with heart failure
Asil H, Demiryürek AT, Düzen IV et al. · Eur J Pharmacol · 2024
Human obs.Endogenous MOTS-c measuredEvidence tier B
What this study reported
Measured higher serum MOTS-c in diabetic patients with heart failure taking SGLT2 inhibitors than in controls, with no corresponding difference in humanin. Also reported higher GPX4 and lower ACSL4 in the SGLT2 inhibitor group, while TFRC was higher in patients and unchanged by SGLT2 inhibitor use.
Limitations
Non-randomised comparison of existing treatment groups, open to confounding by indication; single time point with modest group sizes and no adjustment described in the abstract.
Study record
| Study model | Human observational |
|---|---|
| Substance studied | Endogenous MOTS-c measuredNaturally occurring MOTS-c was measured; nothing was given. |
| Species | human |
| System studied | Serum MOTS-c, humanin, nitrosative stress and ferroptosis markers in diabetic patients with heart failure with reduced ejection fraction, with or without SGLT2 inhibitor use |
| Population | adults with type 2 diabetes and heart failure with reduced ejection fraction, with or without SGLT2 inhibitor treatment, and healthy controls |
| Design | Prospective observational study |
| Sample size as reported | 111 participants (74 patients with diabetes and HFrEF, 37 healthy controls) |
| Control group | healthy controls and patients not taking SGLT2 inhibitors |
| Route (data field only) | Not reported |
| Endpoints measured | serum MOTS-c; serum humanin; nitric oxide and 3-nitrotyrosine; GPX4; ACSL4; TFRC |
| Pathways measured | Oxidative stress · Other |
| Research areas | Cardiovascular · Metabolic |
| Evidence tier | B — Other human study |
| Publication types | Journal Article |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Direct
- Model applicability
- Human
- Sample size
- Small
- Controls
- Limited
- Outcome validity
- Surrogate
- Support for its own conclusion
- Moderate
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.