Study record
The correlation between mitochondrial derived peptide (MDP) and metabolic states: a systematic review and meta-analysis
Zhou Q, Yin S, Lei X et al. · Diabetol Metab Syndr · 2024
ReviewEndogenous MOTS-c measuredEvidence tier R
What this study reported
Pooled seven studies and reported lower circulating MOTS-c in people with diabetes and higher circulating MOTS-c in people with obesity, together with positive correlations between MOTS-c and total and LDL cholesterol.
Limitations
Few included studies, mostly case-control, with substantial heterogeneity and opposite directions between subgroups; assays and populations differ between the pooled studies.
Study record
| Study model | Review |
|---|---|
| Substance studied | Endogenous MOTS-c measuredNaturally occurring MOTS-c was measured; nothing was given. |
| Species | Not reported |
| System studied | Systematic review and meta-analysis of blood MOTS-c concentrations across metabolic states |
| Population | Not reported |
| Design | Systematic review and meta-analysis |
| Sample size as reported | 602 participants across 7 studies (11 groups) |
| Control group | Not reported |
| Route (data field only) | Not reported |
| Endpoints measured | blood MOTS-c concentration; correlation with total cholesterol; correlation with LDL cholesterol |
| Pathways measured | Lipid metabolism · Insulin & glucose handling |
| Research areas | Metabolic |
| Evidence tier | R — Review (context, not evidence) |
| Publication types | Journal Article, Review |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Direct
- Model applicability
- Human
- Sample size
- Small
- Controls
- n/a
- Outcome validity
- Surrogate
- Support for its own conclusion
- Moderate
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.