Study record
The Mitochondrial-Derived Peptide MOTS-c May Refine Mortality and Cardiovascular Risk Prediction in Chronic Hemodialysis Patients: A Multicenter Cohort Study
Bolignano D, Greco M, Presta P et al. · Blood Purif · 2024
Human obs.Endogenous MOTS-c measuredEvidence tier B
What this study reported
Measured higher circulating MOTS-c in haemodialysis patients than in controls and higher levels in the 53 patients who reached the composite endpoint over a median 26.5 months of follow-up. Adding MOTS-c to a model of cohort risk factors improved calibration, discrimination and reclassification.
Limitations
Small single cohort with many events relative to the number of predictors, raising overfitting concerns; no external validation and the control group is not characterised in the abstract.
Study record
| Study model | Human observational |
|---|---|
| Substance studied | Endogenous MOTS-c measuredNaturally occurring MOTS-c was measured; nothing was given. |
| Species | human |
| System studied | Circulating MOTS-c in prevalent haemodialysis patients followed for mortality and cardiovascular events |
| Population | prevalent chronic haemodialysis patients and non-dialysis controls |
| Design | Prospective multicentre observational cohort |
| Sample size as reported | 94 prevalent haemodialysis patients |
| Control group | non-dialysis controls |
| Route (data field only) | Not reported |
| Endpoints measured | circulating MOTS-c; all-cause mortality; non-fatal cardiovascular events; risk model discrimination and reclassification |
| Pathways measured | Not reported |
| Research areas | Kidney · Cardiovascular |
| Evidence tier | B — Other human study |
| Publication types | Journal Article, Multicenter Study, Observational Study |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Direct
- Model applicability
- Human
- Sample size
- Small
- Controls
- Limited
- Outcome validity
- Clinical outcome
- Support for its own conclusion
- Moderate
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.