Study record
The Effect of Chronic Endurance Exercise on Serum Levels of MOTS-c and Humanin in Professional Athletes
Alser M, Ramanjaneya M, Rizwana Anwardeen N et al. · Rev Cardiovasc Med · 2022
What this study reported
Measured serum MOTS-c and humanin by ELISA and reported lower MOTS-c and higher humanin in professional athletes than in sedentary controls. Reported that within the athlete groups humanin was lower in high endurance than in low/moderate endurance athletes of the same sex and age group, that MOTS-c did not differ between those subgroups, and that the two peptides were strongly correlated in athletes but not in controls.
Limitations
Described by the authors as pilot data; cross-sectional single-timepoint sampling with controls not matched for body composition or diet; unequal and small subgroups, particularly the high endurance group; training load characterised only by broad endurance category.
Study record
| Study model | Human observational |
|---|---|
| Substance studied | SeveralMore than one of these is central to the paper (common for reviews). |
| Species | human |
| System studied | Serum MOTS-c and humanin in professional endurance athletes and non-athlete controls, measured by ELISA |
| Population | Professional low/moderate and high endurance athletes and non-athlete sedentary controls |
| Design | Cross-sectional comparison of athletes and non-athletes |
| Sample size as reported | 105 participants (30 non-athlete controls, 47 low/moderate endurance athletes, 28 high endurance athletes) |
| Control group | 30 non-athlete sedentary controls |
| Route (data field only) | Not reported |
| Endpoints measured | serum MOTS-c; serum humanin; correlation between the two peptides |
| Pathways measured | Not reported |
| Research areas | Exercise · Mitochondrial biology |
| Evidence tier | B — Other human study |
| Publication types | Journal Article |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Direct
- Model applicability
- Human
- Sample size
- Small
- Controls
- Limited
- Outcome validity
- Exploratory
- Support for its own conclusion
- Weak
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.