Study record
Neuroprotective Mechanism of MOTS-c in TBI Mice: Insights from Integrated Transcriptomic and Metabolomic Analyses
Li F, Jia Y, Fang J et al. · Drug Des Devel Ther · 2024
AnimalSeveralEvidence tier C
What this study reported
Measured lower MOTS-c expression after traumatic brain injury in mice and reported that peripherally administered MOTS-c entered brain tissue. Reported better memory, learning and motor test performance in treated mice, with transcriptomic and metabolomic changes including lower MIF expression and altered retrograde endocannabinoid signalling.
Limitations
Male mice only with group sizes not reported; omics associations are exploratory and not functionally validated; a single injury model and short behavioural battery.
Study record
| Study model | Animal study (in vivo) |
|---|---|
| Substance studied | SeveralMore than one of these is central to the paper (common for reviews). |
| Species | mouse |
| System studied | Adult male C57BL/6 mice after traumatic brain injury |
| Population | Not reported |
| Design | Controlled animal experiment with transcriptomic and metabolomic profiling |
| Sample size as reported | Not reported |
| Control group | uninjured control mice |
| Route (data field only) | Not reported |
| Endpoints measured | brain MOTS-c expression; memory and learning tests; motor function; brain transcriptome; brain metabolome |
| Pathways measured | Inflammation · Other |
| Research areas | Nervous system |
| Evidence tier | C — Animal in vivo |
| Publication types | Journal Article |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Direct
- Model applicability
- Mammalian
- Sample size
- Not reported
- Controls
- Appropriate
- Outcome validity
- Exploratory
- Support for its own conclusion
- Weak
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.