Study record
The Mitochondrial-Derived Peptide MOTS-c Alleviates Radiation Pneumonitis via an Nrf2-Dependent Mechanism
Zhang Y, Huang J, Zhang Y et al. · Antioxidants (Basel) · 2024
AnimalMOTS-c administeredEvidence tier CAlso: Cell study (in vitro)
What this study reported
Reported that administered MOTS-c was associated with less lung tissue damage, inflammation and oxidative stress in irradiated mice and with reduced apoptosis and mitochondrial damage in mouse lung epithelial cells. The observed effects were absent in Nrf2-deficient mice.
Limitations
Single irradiation model in one mouse strain, with group sizes, sex and blinding not reported; the mechanism rests on one transcription factor and on cell lines.
Study record
| Study model | Animal study (in vivo) |
|---|---|
| Substance studied | MOTS-c administeredSynthetic MOTS-c was given to cells, animals or people. |
| Species | mouse |
| System studied | C57BL/6 mice after thoracic irradiation, plus MLE-12 and primary mouse lung epithelial cells |
| Population | Not reported |
| Design | Controlled animal experiment with cell culture experiments |
| Sample size as reported | Not reported |
| Control group | irradiated mice not given MOTS-c; Nrf2-deficient mice |
| Route (data field only) | intraperitoneal |
| Endpoints measured | lung histology; inflammation; oxidative stress; alveolar epithelial apoptosis; mitochondrial damage; Nrf2 levels and nuclear translocation |
| Pathways measured | NRF2 / antioxidant response · Oxidative stress · Apoptosis · Inflammation |
| Research areas | Lung · Mitochondrial biology |
| Evidence tier | C — Animal in vivo |
| Publication types | Journal Article |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Direct
- Model applicability
- Mammalian
- Sample size
- Not reported
- Controls
- Appropriate
- Outcome validity
- Surrogate
- Support for its own conclusion
- Moderate
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.