Study record
Mitochondria-derived peptide is an effective target for treating streptozotocin induced painful diabetic neuropathy through induction of activated protein kinase/peroxisome proliferator-activated receptor gamma coactivator 1alpha -mediated mitochondrial biogenesis
Xu L, Tang X, Yang L et al. · Mol Pain · 2024
AnimalSeveralEvidence tier C
What this study reported
Measured lower endogenous MOTS-c in plasma and spinal dorsal horn of streptozotocin-treated mice than in controls. Reported that administered MOTS-c was associated with less mechanical allodynia and thermal hyperalgesia, lower blood glucose, higher AMPKα phosphorylation and PGC-1α expression and reduced microglial activation, with these effects blocked by an AMPK inhibitor.
Limitations
Single chemically induced diabetes model in male mice; group sizes and blinding not reported; outcomes are reflex behaviours and marker expression.
Study record
| Study model | Animal study (in vivo) |
|---|---|
| Substance studied | SeveralMore than one of these is central to the paper (common for reviews). |
| Species | mouse |
| System studied | C57BL/6 mice with streptozotocin-induced painful diabetic neuropathy |
| Population | Not reported |
| Design | Controlled animal experiment |
| Sample size as reported | Not reported |
| Control group | vehicle-treated diabetic mice and non-diabetic controls |
| Route (data field only) | Not reported |
| Endpoints measured | plasma and spinal MOTS-c; mechanical allodynia; thermal hyperalgesia; blood glucose and body weight; AMPKα phosphorylation and PGC-1α; microglial activation |
| Pathways measured | AMPK signalling · SIRT1 / PGC-1α / biogenesis · Inflammation |
| Research areas | Nervous system · Metabolic |
| Evidence tier | C — Animal in vivo |
| Publication types | Journal Article, Research Support, Non-U.S. Gov't |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Direct
- Model applicability
- Mammalian
- Sample size
- Not reported
- Controls
- Appropriate
- Outcome validity
- Surrogate
- Support for its own conclusion
- Moderate
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.