Study record
Central MOTS-c infusion affects reproductive hormones in obese and non-obese rats
Ozturk Öztürk DA, Erden Y, Tekin S · Neurosci Lett · 2024
AnimalMOTS-c administeredEvidence tier C
What this study reported
Reported that central MOTS-c infusion was associated with higher hypothalamic GnRH mRNA and protein and higher serum testosterone, LH and FSH in both obese and non-obese male rats, with larger increases in non-obese rats.
Limitations
Males only in a single rat strain; hormone measurements at one end point with no fertility or functional reproductive outcomes; direct ventricular infusion is not comparable to systemic exposure.
Study record
| Study model | Animal study (in vivo) |
|---|---|
| Substance studied | MOTS-c administeredSynthetic MOTS-c was given to cells, animals or people. |
| Species | rat |
| System studied | Male Wistar-Albino rats on a high-fat or normal diet receiving MOTS-c into the lateral ventricles |
| Population | Not reported |
| Design | Controlled animal experiment |
| Sample size as reported | 80 male rats (40 obese, 40 non-obese) in control, sham and two MOTS-c subgroups |
| Control group | sham-infused and untreated rats |
| Route (data field only) | intracerebroventricular |
| Endpoints measured | hypothalamic GnRH mRNA and protein; serum testosterone; serum LH; serum FSH |
| Pathways measured | Other |
| Research areas | Reproductive · Metabolic |
| Evidence tier | C — Animal in vivo |
| Publication types | Journal Article, Research Support, Non-U.S. Gov't |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Direct
- Model applicability
- Mammalian
- Sample size
- Adequate
- Controls
- Appropriate
- Outcome validity
- Surrogate
- Support for its own conclusion
- Moderate
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.