Study record
Impact of Radiation Therapy on Serum Humanin and MOTS-c Levels in Patients with Lung or Breast Cancer
Kavak AG, Karslioglu I, Saracaloglu A et al. · Curr Radiopharm · 2024
Human obs.Endogenous MOTS-c measuredEvidence tier B
What this study reported
Measured higher circulating MOTS-c in patients with lung cancer than in controls and a further increase after radiotherapy. In patients with breast cancer, humanin was lower while MOTS-c was not significantly changed.
Limitations
Small single-centre groups with the control group size not reported; lung cancer patients also received chemotherapy, so changes cannot be attributed to radiotherapy alone.
Study record
| Study model | Human observational |
|---|---|
| Substance studied | Endogenous MOTS-c measuredNaturally occurring MOTS-c was measured; nothing was given. |
| Species | human |
| System studied | Serum MOTS-c and humanin before, during and after radiotherapy in patients with lung or breast cancer and in healthy volunteers |
| Population | patients with stage IIIA/IIIB lung cancer or stage IIA/IIB breast cancer and healthy volunteers |
| Design | Prospective observational case-control study |
| Sample size as reported | 35 lung cancer patients and 34 breast cancer patients plus a healthy control group of unreported size |
| Control group | healthy volunteers |
| Route (data field only) | Not reported |
| Endpoints measured | serum MOTS-c; serum humanin |
| Pathways measured | Not reported |
| Research areas | Cancer |
| Evidence tier | B — Other human study |
| Publication types | Journal Article, Observational Study |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Direct
- Model applicability
- Human
- Sample size
- Small
- Controls
- Limited
- Outcome validity
- Exploratory
- Support for its own conclusion
- Weak
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.